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3-star hotel Check-in 15:00 · Check-out 12:00

Home2 Suites by Hilton Sioux Falls/ Sanford Medical Center, SD

Stay at Home2 Suites by Hilton Sioux Falls/Sanford Medical Center with indoor pool, free breakfast, Wi-Fi, and easy access to Downtown Sioux Falls and Falls Park.

1120 S Grange Ave, Sioux Falls, SD 57105, United States View on map
9.2/10
Exceptional Based on 824 recent guest reviews
Free Wi-Fi Free breakfast Free parking Accessible Indoor pool
What recent guests emphasize

Comfortable suites with attentive service near Sanford Medical Center

Recent visitors highlight the spacious, clean rooms and friendly staff, balanced by occasional concerns about odors on certain floors. The hotel’s convenient location and amenities cater well to medical visitors and families alike.

Guests often praise

  • Spacious, clean all-suite rooms with kitchenettes and good water pressure
  • Friendly, helpful, and empathetic staff who enhance the overall stay
  • Convenient direct connection to Sanford Medical Center via a covered walkway
  • Free breakfast, ample parking, indoor pool, hot tub, and fitness center amenities
  • Quiet atmosphere with quick elevator access and pet-friendly environment

Worth knowing

  • Some guests reported a noticeable odor on the third floor hallway
  • Breakfast quality can vary from day to day
  • No on-site restaurant or airport shuttle service available
  • Housekeeping service may be limited during certain stays

Best for

  • Visitors attending the Sanford Medical Center or managing medical-related stays
  • Families seeking spacious suites with kid- and pet-friendly amenities
  • Guests looking for a quiet, well-equipped hotel close to downtown Sioux Falls
  • Travelers who appreciate complimentary breakfast and convenient parking
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About this property

Welcome to Home2 Suites by Hilton Sioux Falls/ Sanford Medical Center, SD

Home2 Suites by Hilton Sioux Falls/Sanford Medical Center is a contemporary all-suite hotel located at 1120 S Grange Ave, conveniently connected to Sanford Medical Center by a covered walkway. This positioning makes it a practical choice for visitors with ties to the medical center, while Downtown Sioux Falls and Falls Park are just a mile and three miles away, respectively, offering easy access to local attractions.

The property features spacious suites, many equipped with kitchenettes, catering well to extended stays or guests who prefer preparing their own meals. Amenities include a fitness center, an indoor pool, and a hot tub, alongside free Wi-Fi, parking, and breakfast. The hotel is smoke-free, pet-friendly, and accessible, with air conditioning throughout. Although there is no on-site restaurant or business center, the facilities meet the basic needs of both short-term and long-term visitors.

Guest reviews generally commend the hotel's cleanliness, helpful staff, and comfortable accommodations, though some have noted occasional issues such as a temporary odor on an upper floor and variable breakfast quality. The friendly service, in particular from front desk staff, is highlighted as a positive aspect that adds to the stay experience, especially for those managing medical visits nearby.

For leisure activities, Falls Park offers scenic outdoor spaces with waterfalls and picnic areas, while the Great Plains Zoo and Old Courthouse Museum provide cultural and family-friendly options within a short drive. Sioux Falls Regional Airport is approximately 19 minutes away by car, enhancing accessibility for travelers.

Summary compiled by GoHotelly editors from verified guest reviews, partner descriptions and editorial notes.
Facilities & essentials

What's on-site and what you should know before you arrive

The short version: what's available day-to-day, and the key practical details most travelers search for.

Most popular facilities

Free Wi-Fi
Free breakfast
Free parking
Accessible
Indoor pool
Air-conditioned
Pet-friendly
Kid-friendly
Kitchens in some rooms
Hot tub
Fitness center
Smoke-free

Not available at this property

Business center
Restaurant
Airport shuttle
Verified guest reviews

What recent guests are actually saying

Reviews from travelers who stayed here in the last 12 months, grouped to help you spot the pattern quickly.

HJ
Heather Janssen Apr 05, 2026
10

Our favorite hotel to stay when visiting Sioux Falls! The cleanliness of the establishment & the customer service beats anywhere else we've stayed at by far! Highly recommend!

DA
Dee A Mar 25, 2026
10

The staff was so sweet and helpful, breakfast was good, hot and fresh! They made my stay feel comfortable while my loved one was in the hospital, They care about your needs. Definitely will stay again. Thank you Natalie the front desk staff, she was amazing!

RJ
Rick John Mar 20, 2026
8.0

Overall a nice place. Rooms are spacious and clean. Amenities are nice. Only bad thing was the odor on third floor - smelled like urine diapers that had been left out for extended period of time. Didn’t matter where I walked on third hallway - odor was present. No odor on main floor.

RA
RITA Auch Feb 17, 2026
10

The hotel staff was very helpful and accommodating. The lady at the front desk in the afternoons was amazing she was so empathetic and kind when I shared about my sister’s stay in the hospital. The cleaning crew was also friendly and quick to bring anything we needed.

BF
Beth Ferguson Feb 16, 2026
10

Received a phone call from the motel en route apologizing for not being able to accommodate our request for first floor but said they would have a room ready when we got there. We arrived an hour and a half before check in (still quite surprised we could get that soon) and the lady that called us also checked us in. Her name was Natalie and she was very welcoming. We were in SF for a basketball tournament. The night desk attendant was great by cheering on our team when we went out and filling in the bracket when we returned. Her name was Destiny and she definitely made our stay more fun and enjoyable! The motel is quiet and the location is perfect for attending sporting events, concerts, or managing medical visits. If you have a dog, there is ample green spaces available. Elevators are quick and breakfast is well supplied. Really enjoyed our stay!

AK
Alexander K Jan 15, 2026
10

Very impressive Hilton hotels chain. Home2Suits has been our go to for the past few years. For the price you get absolutely everything you may possibly need from a hotel room

KW
Kaci Welch Jan 08, 2026
10

Really impressed with this location. The room was great, as was the pool. Plenty of parking available too!! Breakfast was kinda meh, but I think we just caught them on a bad day.

YW
Yao Wong Dec 29, 2025
8.0

Directly connected to the hospital. Rooms are fine - they have kitchenettes and the beds are decent. Good water pressure in the shower. We didn't get housekeeping so can't comment on that. Breakfast items rotated over the few days we stayed - not bad for a free offering. Gym is better than average for a 3*hotel. Pool and hot tub were a nice amenity too. Ample parking.

Location & neighborhood

Where you'll find Home2 Suites by Hilton Sioux Falls/ Sanford Medical Center, SD

Sioux Falls, South Dakota, USA

Connected to Sanford Medical Center via a covered walkway, this modern all-suite hotel is a mile from Downtown Sioux Falls and 3 miles from Falls Park.

  • Grange/18th SW 2 min Walk
  • Minnesota/19th SE 12 min Walk
  • Grange/18th SE 2 min Walk
  • Sioux Falls Regional Airport 19 min Car · 34 min Transit
Things to do nearby

Worth the walk or a quick ride

Curated spots travelers usually pair with a stay in South Dakota. Distances are rough real-world times, not straight-line.

Falls Park 14,270 reviews

Falls Park

131 E Falls Park Dr, Sioux Falls, SD 57104, United States

4.8 · Park
Great Plains Zoo 3,291 reviews

Great Plains Zoo

805 S Kiwanis Ave, Sioux Falls, SD 57104, United States

4.4 · Zoo
Old Courthouse Museum 763 reviews

Old Courthouse Museum

200 W 6th St, Sioux Falls, SD 57104, United States

4.7 · Historical Place Museum
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